Kostas T. Konstantinidis

Richard C. Tucker Professor
Telephone
Office Building
EST
Office Room Number
3202
Biography

Dr. Kostas Konstantinidis is the Richard C. Tucker Professor in the School of Civil and Environmental Engineering and the School of Biological Sciences (adjunct) at Georgia Tech and Program Faculty for the Coulter Department of Biomedical Engineering at Georgia Tech and Emory University. He earned his BS (1999) in Agricultural Sciences from the Aristotle University of Thessaloniki, Greece and his PhD (2004) from the Center for Microbial Ecology at Michigan State University, under the supervision of James Tiedje. Prior to joining the faculty at Georgia Tech in 2007, he was a Postdoctoral Fellow in the Department of Civil and Environmental Engineering at MIT under the supervision of Ed DeLong. Dr. Konstantinidis has published ~240 peer-reviewed articles in the areas that he performs research in, which have received in excess of 42,000 citations (Google Scholar). Accordingly, he has made the top 1% of world's Highly Cited scientists and engineers list by Clarivate/Web of Science since 2020. He has received several distinctions and awards for his work, including to be an elected member of the honorary American Academy of Microbiology (ASM), and a 2025-2026 ASM Distinguished Lecturer. See also lab website for further details at: http://enve-omics.gatech.edu

Research

The overarching goal of Dr. Konstantinidis’ research is to advance understanding of how microorganisms adapt to human-induced environmental perturbations and to cause disease. He is also interested in biotechnological applications of microbial diversity in the bioremediation of environmental pollutants and the assessment of water quality. The great majority of microorganisms resists cultivation in the laboratory and thus, cannot be studied efficiently. Therefore, another major objective of Dr. Konstantinidis’ research program is to develop novel culture-independent (aka metagenomics and metatranscriptomics) approaches and the associated bioinformatics tools to study microbial communities in-situ, in both natural (e.g., terrestrial or marine) as well as human-associated (e.g., wastewater treatment plants, the human gut) systems. The bioinformatics tools are made freely available online through a dedicated webserver (https://enveomics.scigap.org) for analysis of microbial genomic and metagenomic data by external users, and for educational purposes. Currently, >3,000 users per month use this webserver. Dr. Konstantinidis’ research has addressed several pressing questions in these areas such as what is a microbial species and how species evolve, and provided biomarkers for fecal pollution tracking and biodegradation of important contaminants. Accordingly, he is considered a world leader in the fields of microbiome engineering and genomics. More details on active research projects in the lab are provided through the lab website (https://enve-omics.gatech.edu/ongoing-projects/).

Education
Post-doc M.I.T   08/2005-08/2007
Post-doc Michigan State University 01/2005-07/2005
Ph.D. Michigan State University 2004
B.S. Aristotle University, Thessaloniki, Greece  1999
Teaching

Dr. Konstantinidis has developed new graduate and undergraduate courses that fulfill critical needs in the curriculum of Environmental Engineering, and more specifically, the intersection of microbiology with environmental biotechnology and engineered systems, such as #3 below. He frequently teaches the following courses with notable success based on student exit interviews and ratings, as well as students’ success in finding jobs and internships in industry and academia:

  1. CEE2300. Environmental Engineering Principles. Fundamental physical, chemical and biological principles are introduced and highlighted using specific environmental examples. An overall objective for the course is to develop and utilize fundamental principles in environmental systems.
  2. CEE6311. Microbial Principles. This course is an overview of basic and applied themes in microbiology. The course introduces principles of microbiology including microbial diversity, microbial evolution, metabolic diversity, and microbial ecology. Microbial processes for industrial and biotechnological applications will be discussed. Specific topics related to environmental engineering receive particular focus, including microbial nutrition and growth, water and wastewater microbiology, biochemical thermodynamics, and microbial kinetics.
  3. CEE/BIOL6720. Environmental Microbial Genomics. The objectives for the course are to expose students to advanced concepts and principles of contemporary microbiological research and associated bioinformatics techniques through representative examples from recent literature. Topics covered include, but are not limited to: the value of diversity of microbial genes and genomes for the lifesustaining biogeochemical cycles, disease control, and biotechnology; the complexity of microbial communities; the interactions among microbes and their environment; and the influence of the environment in shaping and driving the evolution of microbial genomes and microbial communities. The course also offers an extensive discussion of the cutting-edge technologies and methodologies that enable contemporary research. Emphasis is given on “How-To” tackle recurrent research problems through bioinformatics exercises, which make up about 2/3 of the course.
Distinctions & Awards
  • 2021-2025: Top 1% of world's highly cited scientists & engineers by Clarivate/Web of Science
  • 2025-2026: American Society for Microbiology (ASM) Distinguished Lecturer
  • 2021: Georgia Tech’s Outstanding Faculty Research Author Award
  • 2020: Elected member, honorary American Academy of Microbiology
  • 2014: Kavli Frontiers of Science Fellowship
  • 2012: Appointed to the Carlton S. Wilder Junior Chair in Environmental Engineering
  • 2012: Sigma Xi Young Faculty Research Award (Sigma Xi’s Georgia Tech Branch)
  • 2010: Recipient of the International Skerman Award for Prokaryotic Taxonomy
  • 2007: Distinguished Scientist Abroad Award. Hellenic National Defense General Staff
  • 2000-2004: Bouyoukos Fellowship (full-time support during PhD studies)
Publications

Selected Publications (out of 240 in total; *denotes student/postdoc advisee) Up-to-date citation statistics for Dr. Konstantinidis are also available on Web of Science.

  1. R. E. Conrad*, C. E. Brink*, T. Viver, L. M. Rodriguez-R, B. Aldeguer-Riquelme, J. K. Hatt, S. N. Venter, R. Rossello-Mora, R. Amann, and K. T. Konstantinidis. Microbial species and intraspecies units exist and are maintained by ecological cohesiveness coupled to high homologous recombination. Nat Commun. 2024. doi: 10.1038/s41467-024-53787-0.
  2. 2. T. Viver, R. E. Conrad*, L. M. Rodriguez-R, A. S. Ramírez, S. N. Venter, J. Rocha-Cárdenas, R. Amann, K. T. Konstantinidis, and R. Rossello-Mora. Towards estimating the number of strains that make up a natural bacterial population. Nature Communi. 2024. doi: 10.1038/s41467-023-44622-z.
  3. 3. J. Zhao*, J. P. Both, L. M. Rodriguez-R, and K. T. Konstantinidis KT. GSearch: ultra-fast and scalable genome search by combining K-mer hashing with hierarchical navigable small world graphs. Nucleic Acids Res. 2024. doi: 10.1093/nar/gkae609.
  4. L. M. Rodriguez-R, R. E. Conrad*, T. Viver, D. J. Feistel*, B. G. Lindner*, S. N. Venter, L. H. Orellana, R. Amann, R. Rossello-Mora, and K. T. Konstantinidis. An ANI gap within bacterial species that advances the definitions of intra-species units. mBio. 2023. doi: 10.1128/mbio.02696-23.
  5. G. Cha*, K. E. Graham*, K. J. Zhu*, G. Rao, B. Lindner*, K. Kocaman*, S. Woo*, I. D'amico*, L. R. Bingham*, J. M. Fischer*, C. I. Flores*, J. W. Spencer*, P. Yathiraj*, […], J. Brown, A. Bryksin, A. Pinto, J. K. Hatt, K. T. Konstantinidis. Parallel deployment of passive and composite samplers for surveillance and variant profiling of SARS-CoV-2 in sewage. Sci. Total Environ. 2023.
  6. M. H. Seabolt*, D. M. Roellig, and K. T. Konstantinidis. Genomic comparisons confirm Giardia duodenalis sub-assemblage AII as a unique species. Front Cell Infect Microbiol. 12:1010244. 2022.
  7. B. G. Lindner*, B. Suttner*, K. J. Zhu*, R. E. Conrad*, L. M. Rodriguez-R*, J. K. Hatt, J. Brown, and K. T. Konstantinidis. Toward shotgun metagenomic approaches for microbial source tracking sewage spills based on laboratory mesocosms. Water Research. 210:117993. 2022.
  8. S. Karthikeyan*, M. Kim*,…, J. E. Kostka, and K. T. Konstantinidis. Integrated Omics Elucidate the Mechanisms Driving the Rapid Biodegradation of Deepwater Horizon Oil in Intertidal Sediments Undergoing Oxic-Anoxic Cycles. Environ Sci Technol. 54(16):10088-10099. 2020.
  9. E. R. Johnston*, J. K. Hatt, Z. He, L. Wu, X. Guo, Y. Luo, E. A. G. Schuur, J. M. Tiedje, J. Zhou, and K. T. Konstantinidis. Responses of tundra soil microbial communities to half a decade of experimental warming at two critical depths. PNAS. 116(30):15096-15105. 2019.
  10. S. Karthikeyan*, L. M. Rodriguez-R*, P. Heritier-Robbins*, M. Kim*,…, M. Huettel, J. E. Kostka, and K. T. Konstantinidis. "Candidatus Macondimonas diazotrophica", a novel gammaproteobacterial genus dominating crude-oil-contaminated coastal sediments. ISME J. 13(8):2129-2134. 2019.

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